Influence of Magnetic Nanoparticle Degradation in the Frame of Magnetic Hyperthermia and Photothermal Treatments
نویسندگان
چکیده
This work aims at studying how the transformations that magnetic nanoparticles suffer in vivo affect their heating properties frame of hyperthermia treatments. Iron oxide (≈13 nm) with two different coatings [PMAO (polymaleic anhydride-alt-1-octadecene) and DMSA (dimercaptosuccinic acid)] have been subjected to an accelerated degradation a medium simulating lysosome conditions. The particles physicochemical (size, size distribution, properties) followed over process along 24 days. It was found DMSA-coated degraded much faster than PMAO-coated ones. In addition, under both exposure alternating field or near infrared light tracked this processes, assessing changes capacity. Along procedure, stronger decrease has observed measurements, comparison photothermal Finally, selected for study after intratumoral administration. Interestingly, although number decreases time tissue, distribution do not change significantly time. is especially relevant design treatments using as it would provide fundamental clues regarding need repeated doses possible use single administration depending on treatment duration.
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ژورنال
عنوان ژورنال: ACS applied nano materials
سال: 2022
ISSN: ['2574-0970']
DOI: https://doi.org/10.1021/acsanm.2c03220